CCH attack frequency reduction after psilocybin correlates with hypothalamic functional connectivity.
Headache
; 64(1): 55-67, 2024 01.
Article
en En
| MEDLINE
| ID: mdl-38238974
ABSTRACT
OBJECTIVE:
To evaluate the feasibility and prophylactic effect of psilocybin as well as its effects on hypothalamic functional connectivity (FC) in patients with chronic cluster headache (CCH).BACKGROUND:
CCH is an excruciating and difficult-to-treat disorder with incompletely understood pathophysiology, although hypothalamic dysfunction has been implicated. Psilocybin may have beneficial prophylactic effects, but clinical evidence is limited.METHODS:
In this small open-label clinical trial, 10 patients with CCH were included and maintained headache diaries for 10 weeks. Patients received three doses of peroral psilocybin (0.14 mg/kg) on the first day of weeks five, six, and seven. The first 4 weeks served as baseline and the last 4 weeks as follow-up. Hypothalamic FC was determined using functional magnetic resonance imaging the day before the first psilocybin dose and 1 week after the last dose.RESULTS:
The treatment was well tolerated. Attack frequency was reduced by mean (standard deviation) 31% (31) from baseline to follow-up (pFWER = 0.008). One patient experienced 21 weeks of complete remission. Changes in hypothalamic-diencephalic FC correlated negatively with a percent change in attack frequency (pFWER = 0.03, R = -0.81), implicating this neural pathway in treatment response.CONCLUSION:
Our results indicate that psilocybin may have prophylactic potential and implicates the hypothalamus in possible treatment response. Further clinical studies are warranted.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Psilocibina
/
Cefalalgia Histamínica
Límite:
Humans
Idioma:
En
Revista:
Headache
Año:
2024
Tipo del documento:
Article
País de afiliación:
Dinamarca