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Risk of gastric adenoma and adenocarcinoma in patients with familial adenomatous polyposis in Japan: a nationwide multicenter study.
Sasaki, Kazuhito; Kawai, Kazushige; Nozawa, Hiroaki; Ishihara, Soichiro; Ishida, Hideyuki; Ishibashi, Keiichiro; Mori, Yoshiko; Shichijo, Satoki; Tani, Yasuhiro; Takeuchi, Yoji; Chino, Akiko; Takao, Misato; Fujiyoshi, Kenji; Matsubara, Takaaki; Miyakura, Yasuyuki; Taniguchi, Fumitaka; Yamaguchi, Tatsuro; Tanakaya, Kohji; Tomita, Naohiro; Ajioka, Yoichi.
Afiliación
  • Sasaki K; Department of Surgical Oncology, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan. sasakik-tky@umin.ac.jp.
  • Kawai K; The Committee of Hereditary Colorectal Cancer, Japanese Society for Cancer of the Colon and Rectum, Tokyo, Japan. sasakik-tky@umin.ac.jp.
  • Nozawa H; Department of Surgical Oncology, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan.
  • Ishihara S; Department of Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan.
  • Ishida H; Department of Surgical Oncology, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan.
  • Ishibashi K; Department of Surgical Oncology, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan.
  • Mori Y; The Committee of Hereditary Colorectal Cancer, Japanese Society for Cancer of the Colon and Rectum, Tokyo, Japan.
  • Shichijo S; Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Saitama, Japan.
  • Tani Y; Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Saitama, Japan.
  • Takeuchi Y; Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Saitama, Japan.
  • Chino A; The Committee of Hereditary Colorectal Cancer, Japanese Society for Cancer of the Colon and Rectum, Tokyo, Japan.
  • Takao M; Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan.
  • Fujiyoshi K; Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan.
  • Matsubara T; Department of Genetic Oncology, Division of Hereditary Tumors and Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan.
  • Miyakura Y; The Committee of Hereditary Colorectal Cancer, Japanese Society for Cancer of the Colon and Rectum, Tokyo, Japan.
  • Taniguchi F; Department of Gastroenterology, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan.
  • Yamaguchi T; Department of Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan.
  • Tanakaya K; The Committee of Hereditary Colorectal Cancer, Japanese Society for Cancer of the Colon and Rectum, Tokyo, Japan.
  • Tomita N; Department of Surgery, Kurume University School of Medicine, Kurume, Japan.
  • Ajioka Y; The Committee of Hereditary Colorectal Cancer, Japanese Society for Cancer of the Colon and Rectum, Tokyo, Japan.
J Gastroenterol ; 59(3): 187-194, 2024 03.
Article en En | MEDLINE | ID: mdl-38263336
ABSTRACT

BACKGROUND:

Patients with familial adenomatous polyposis (FAP) have an increased risk of developing gastric neoplasms. However, the clinical course of FAP with these gastric lesions has not yet been fully clarified. The present study aimed to clarify the changes in the incidence risk of developing gastric adenoma or gastric cancer during the lifespan of patients with FAP.

METHODS:

Four hundred forty-three patients with data regarding gastric adenoma and gastric cancer retrospectively registered in a nationwide Japanese multicenter study were enrolled. The cumulative incidences and hazard rates (HRs) of gastric neoplasms were evaluated.

RESULTS:

The cumulative incidence rates in 50-year-old patients with FAP were 22.8% for gastric adenoma and 7.6% for gastric cancer, respectively. No significant association was found between gastric neoplasms and the colonic phenotype. The peak age for the HR of gastric adenoma was 65 years, with the highest HR (0.043). Regarding the incidence of gastric cancer, the HR increased moderately up to the age of 40 years, but the increase accelerated from the age of 50 years (HR = 0.0067).

CONCLUSION:

Careful surveillance of the upper gastrointestinal tract in elderly patients with FAP, such as shortening the interval of follow-up according to age, may be helpful for early diagnosis of gastric cancer.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Neoplasias Gástricas / Adenocarcinoma / Pólipos Adenomatosos / Poliposis Adenomatosa del Colon Tipo de estudio: Clinical_trials / Etiology_studies / Risk_factors_studies / Screening_studies Límite: Adult / Aged / Humans / Middle aged País/Región como asunto: Asia Idioma: En Revista: J Gastroenterol Asunto de la revista: GASTROENTEROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Japón
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Neoplasias Gástricas / Adenocarcinoma / Pólipos Adenomatosos / Poliposis Adenomatosa del Colon Tipo de estudio: Clinical_trials / Etiology_studies / Risk_factors_studies / Screening_studies Límite: Adult / Aged / Humans / Middle aged País/Región como asunto: Asia Idioma: En Revista: J Gastroenterol Asunto de la revista: GASTROENTEROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Japón