The Gut Microbiota and Major Depressive Disorder: Current Understanding and Novel Therapeutic Strategies.
Curr Pharm Biotechnol
; 25(16): 2089-2107, 2024.
Article
en En
| MEDLINE
| ID: mdl-38288791
ABSTRACT
Major depressive disorder (MDD) is a common neuropsychiatric challenge that primarily targets young females. MDD as a global disorder has a multifactorial etiology related to the environment and genetic background. A balanced gut microbiota is one of the most important environmental factors involved in human physiological health. The interaction of gut microbiota components and metabolic products with the hypothalamic-pituitary-adrenal system and immune mediators can reverse depression phenotypes in vulnerable individuals. Therefore, abnormalities in the quantitative and qualitative structure of the gut microbiota may lead to the progression of MDD. In this review, we have presented an overview of the bidirectional relationship between gut microbiota and MDD, and the effect of pre-treatments and microbiomebased approaches, such as probiotics, prebiotics, synbiotics, fecal microbiota transplantation, and a new generation of microbial alternatives, on the improvement of unstable clinical conditions caused by MDD.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Probióticos
/
Trastorno Depresivo Mayor
/
Prebióticos
/
Trasplante de Microbiota Fecal
/
Microbioma Gastrointestinal
Tipo de estudio:
Qualitative_research
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Pharm Biotechnol
Asunto de la revista:
BIOTECNOLOGIA
/
FARMACOLOGIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Irán