A neonatal piglet model reveals interactions between nasal microbiota and influenza A virus pathogenesis.
Virology
; 592: 109996, 2024 04.
Article
en En
| MEDLINE
| ID: mdl-38301448
ABSTRACT
While vaccination and therapeutics for prevention/treatment of influenza are available, new strategies are needed to combat influenza disease in susceptible populations, particularly young children and newborns. Host associated microbiota play an important role in modulating the virulence of numerous pathogens, including the influenza A virus. In this study, we examined microbiome-influenza interactions in a neonatal piglet model system. The nasal microbiome of newborn piglets was longitudinally sampled before and after intranasal infection with recombinant viruses expressing hemagglutinins (HAs) derived from distinct zoonotic H1 subtypes. We found that viruses expressing different parental HAs manifested unique patterns of pathogenicity, and varied impacts on microbial community diversity. Despite these virus specific differences, a consistent microbial signature of viral infection was detected. Our results indicate that influenza A virus infection associates with the restructuring of nasal microbiome and such shifts in microbial diversity may contribute to outcomes of viral infection in neonatal piglets.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Virus de la Influenza A
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Infecciones por Orthomyxoviridae
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Gripe Humana
/
Microbiota
Tipo de estudio:
Etiology_studies
Límite:
Animals
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Child
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Child, preschool
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Humans
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Newborn
Idioma:
En
Revista:
Virology
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos