An adenovirus-vectored vaccine based on the N protein of feline coronavirus elicit robust protective immune responses.
Antiviral Res
; 223: 105825, 2024 Mar.
Article
en En
| MEDLINE
| ID: mdl-38311297
ABSTRACT
Feline coronavirus (FCoV) is an unsegmented, single-stranded RNA virus belonging to the Alphacoronavirus genus. It can cause fatal feline infectious peritonitis (FIP) in cats of any ages. Currently, there are no effective prevention and control measures to against FCoV. In this study, we developed a recombinant adenovirus vaccine, AD5-N, based on the nucleocapsid(N) protein of FCoV. The immunogenicity of AD5-N was evaluated through intramuscular immunization in 6-week-old Balb/c mice and 9-12 months old cats. Compared to the control group, AD5-N specifically induced a significant increase in IgG and SIgA levels in the vaccinated mice. Furthermore, AD5-N not only effectively promoted strong cellular immune responses in cats but also induced high levels of specific SIgA, effectively helping cats resist FCoV infection. Our findings suggest that adenovirus vector vaccines based on the N gene have the potential to become candidate vaccines for the prevention and control of FCoV infection.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Vacunas
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Infecciones por Coronavirus
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Infecciones por Adenoviridae
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Coronavirus Felino
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Vacunas contra el Adenovirus
Límite:
Animals
Idioma:
En
Revista:
Antiviral Res
Año:
2024
Tipo del documento:
Article