Persistent immune abnormalities discriminate post-COVID syndrome from convalescence.
Infection
; 52(3): 1087-1097, 2024 Jun.
Article
en En
| MEDLINE
| ID: mdl-38326527
ABSTRACT
BACKGROUND:
Innate lymphoid cells (ILCs) are key organizers of tissue immune responses and regulate tissue development, repair, and pathology. Persistent clinical sequelae beyond 12 weeks following acute COVID-19 disease, named post-COVID syndrome (PCS), are increasingly recognized in convalescent individuals. ILCs have been associated with the severity of COVID-19 symptoms but their role in the development of PCS remains poorly defined. METHODS ANDRESULTS:
Here, we used multiparametric immune phenotyping, finding expanded circulating ILC precursors (ILCPs) and concurrent decreased group 2 innate lymphoid cells (ILC2s) in PCS patients compared to well-matched convalescent control groups at > 3 months after infection or healthy controls. Patients with PCS showed elevated expression of chemokines and cytokines associated with trafficking of immune cells (CCL19/MIP-3b, FLT3-ligand), endothelial inflammation and repair (CXCL1, EGF, RANTES, IL-1RA, PDGF-AA).CONCLUSION:
These results define immunological parameters associated with PCS and might help find biomarkers and disease-relevant therapeutic strategies.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Linfocitos
/
Convalecencia
/
Citocinas
/
COVID-19
/
Síndrome Post Agudo de COVID-19
Tipo de estudio:
Prognostic_studies
Límite:
Adult
/
Aged
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Infection
Año:
2024
Tipo del documento:
Article
País de afiliación:
Alemania