Middle Molecular Uremic Toxin and Blood Purification Therapy.
J Clin Med
; 13(3)2024 Jan 23.
Article
en En
| MEDLINE
| ID: mdl-38337341
ABSTRACT
The purpose of blood purification therapy is to remove uremic toxins, and middle molecules (MMs) are a specific target. An MM is defined as a solute that passes through the glomerulus with a molecular weight in the range of 0.5-58 kDa, and new classifications of "small-middle 0.5-15 kDa," "medium-middle 15-25 kDa," and "large-middle 25-58 kDa" were proposed. In Japan, the removal of α1-microglobulin (αMG) in the large-middle range has been the focus, but a new theory of removal has been developed, emphasizing the antioxidant effect of αMG as a physiological function. Clinical proof of this mechanism will lead to further development of blood purification therapies.
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Base de datos:
MEDLINE
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En
Revista:
J Clin Med
Año:
2024
Tipo del documento:
Article
País de afiliación:
Japón