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Fatty acid metabolism-related lncRNA prognostic signature for serous ovarian carcinoma.
Ye, Lele; Jiang, Zhuofeng; Zheng, Mengxia; Pan, Kan; Lian, Jingru; Ju, Bing; Liu, Xuefei; Tang, Sangsang; Guo, Gangqiang; Zhang, Songfa; Hong, Xin; Lu, Weiguo.
Afiliación
  • Ye L; Women's Reproductive Health Laboratory of Zhejiang Province, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, Zhejiang, China.
  • Jiang Z; Department of Biochemistry, School of Medicine, Southern University of Science & Technology, Shenzhen, 518055, Guangdong, China.
  • Zheng M; Women's Reproductive Health Laboratory of Zhejiang Province, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, Zhejiang, China.
  • Pan K; First Clinical College, Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China.
  • Lian J; Department of Biochemistry, School of Medicine, Southern University of Science & Technology, Shenzhen, 518055, Guangdong, China.
  • Ju B; Department of Biochemistry, School of Medicine, Southern University of Science & Technology, Shenzhen, 518055, Guangdong, China.
  • Liu X; Department of Biochemistry, School of Medicine, Southern University of Science & Technology, Shenzhen, 518055, Guangdong, China.
  • Tang S; Women's Reproductive Health Laboratory of Zhejiang Province, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, Zhejiang, China.
  • Guo G; Wenzhou Collaborative Innovation Center of Gastrointestinal Cancer in Basic Research & Precision Medicine, Wenzhou Key Laboratory of Cancer-related Pathogens & Immunity, Department of Microbiology & Immunology, Institute of Molecular Virology & Immunology, Institute of Tropical Medic
  • Zhang S; Department of Gynecologic Oncology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, Zhejiang, China.
  • Hong X; Department of Biochemistry, School of Medicine, Southern University of Science & Technology, Shenzhen, 518055, Guangdong, China.
  • Lu W; Key University Laboratory of Metabolism & Health of Guangdong, Southern University of Science & Technology, Shenzhen, 518055, Guangdong, China.
Epigenomics ; 16(5): 309-329, 2024 Mar.
Article en En | MEDLINE | ID: mdl-38356435
ABSTRACT

Background:

To explore the role of fatty acid metabolism (FAM)-related lncRNAs in the prognosis and antitumor immunity of serous ovarian cancer (SOC). Materials &

methods:

A SOC FAM-related lncRNA risk model was developed and evaluated by a series of analyses. Additional immune-related analyses were performed to further assess the associations between immune state, tumor microenvironment and the prognostic risk model.

Results:

Five lncRNAs associated with the FAM genes were found and used to create a predictive risk model. The patients with a low-risk profile exhibited favorable prognostic outcomes.

Conclusion:

The established prognostic risk model exhibits better predictive capabilities for the prognosis of patients with SOC and offers novel potential therapy targets for SOC.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Neoplasias Ováricas / ARN Largo no Codificante Tipo de estudio: Prognostic_studies Límite: Female / Humans Idioma: En Revista: Epigenomics Año: 2024 Tipo del documento: Article País de afiliación: China
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Neoplasias Ováricas / ARN Largo no Codificante Tipo de estudio: Prognostic_studies Límite: Female / Humans Idioma: En Revista: Epigenomics Año: 2024 Tipo del documento: Article País de afiliación: China