Direct Synthesis of Aryloxy Phosphonamidate Nucleotide Prodrugs Using the Cross Metathesis Assisted by Ultrasonic Irradiation.
Org Lett
; 26(23): 4841-4846, 2024 Jun 14.
Article
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| MEDLINE
| ID: mdl-38381649
ABSTRACT
A direct synthetic strategy of aryloxy phosphonamidate nucleotide prodrugs (A, G, C, and U) was developed with the CM reaction assisted by ultrasonic irradiation and partitioned addition of 12 mol % of Hoveyda-Grubbs (H-G) II catalyst in 61-82% yields as a mixture of E-/Z-isomers (â¼21) from aryloxy vinylphosponamidate and 5'-vinyl nucleoside moieties.
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Base de datos:
MEDLINE
Asunto principal:
Profármacos
Idioma:
En
Revista:
Org Lett
Asunto de la revista:
BIOQUIMICA
Año:
2024
Tipo del documento:
Article