Hourglass, a compass navigating global and regional heterogeneity of pancreatic cancer.
J Pathol
; 263(1): 5-7, 2024 05.
Article
en En
| MEDLINE
| ID: mdl-38404051
ABSTRACT
Advances in the digital pathology field have facilitated the characterization of histology samples for both clinical and preclinical research. However, uncovering subtle correlations between bioimaging, clinical and molecular parameters requires extensive statistical analysis. As a user-friendly software, Hourglass, simplifies multiparametric dataset analysis through intuitive data visualization and statistical tools. Systemic analysis of interleukin-6 (IL-6)/pStat3 signaling pathway through Hourglass revealed differences in regional immune cell composition within tumors. Moreover, these regional disparities were partially mediated by sex. Overall, Hourglass simplifies information extraction from complex datasets, resolving overlooked regional and global spatial tumor differences. © 2024 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Pancreáticas
Límite:
Humans
País/Región como asunto:
Europa
Idioma:
En
Revista:
J Pathol
Año:
2024
Tipo del documento:
Article
País de afiliación:
Alemania