Pipeline of Novel Antifungals for Invasive Fungal Disease in Transplant Recipients: A Pediatric Perspective.
J Pediatric Infect Dis Soc
; 13(Supplement_1): S68-S79, 2024 Feb 28.
Article
en En
| MEDLINE
| ID: mdl-38417087
ABSTRACT
Invasive fungal disease (IFD) remains a significant cause of morbidity and mortality in children undergoing transplantation. There is a growing armamentarium of novel antifungal agents recently approved for use or in late stages of clinical development. The overarching goal of this review is to discuss the mechanisms of action, spectrum of activity, stage of development, and pediatric-specific data for the following agents encochleated amphotericin B deoxycholate, fosmanogepix, ibrexafungerp, isavuconazole, olorofim, opelconazole, oteseconazole, and rezafungin. Additionally, key drug attributes of these novel agents and their potential future therapeutic roles in pediatric transplant recipients are discussed.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Infecciones Fúngicas Invasoras
/
Micosis
Límite:
Child
/
Humans
Idioma:
En
Revista:
J Pediatric Infect Dis Soc
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos