A guideline on the molecular ecosystem regulating ferroptosis.
Nat Cell Biol
; 26(9): 1447-1457, 2024 Sep.
Article
en En
| MEDLINE
| ID: mdl-38424270
ABSTRACT
Ferroptosis, an intricately regulated form of cell death characterized by uncontrolled lipid peroxidation, has garnered substantial interest since this term was first coined in 2012. Recent years have witnessed remarkable progress in elucidating the detailed molecular mechanisms that govern ferroptosis induction and defence, with particular emphasis on the roles of heterogeneity and plasticity. In this Review, we discuss the molecular ecosystem of ferroptosis, with implications that may inform and enable safe and effective therapeutic strategies across a broad spectrum of diseases.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Peroxidación de Lípido
/
Ferroptosis
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Nat Cell Biol
Año:
2024
Tipo del documento:
Article
País de afiliación:
China