A review of fatty acid oxidation disorder mouse models.
Mol Genet Metab
; 142(1): 108351, 2024 May.
Article
en En
| MEDLINE
| ID: mdl-38430613
ABSTRACT
Fatty acid oxidation disorders (FAODs) are a family of rare, genetic disorders that affect any part of the fatty acid oxidation pathway. Patients present with severe phenotypes, such as hypoketotic hypoglycemia, cardiomyopathy, and rhabdomyolysis, and currently manage these symptoms by the avoidance of fasting and maintaining a low-fat, high-carbohydrate diet. Because knowledge about FAODs is limited due to the small number of patients, rodent models have been crucial in learning more about these disorders, particularly in studying the molecular mechanisms involved in different phenotypes and in evaluating treatments for patients. The purpose of this review is to present the different FAOD mouse models and highlight the benefits and limitations of using these models. Specifically, we discuss the phenotypes of the available FAOD mouse models, the potential molecular causes of prominent FAOD phenotypes that have been studied using FAOD mouse models, and how FAOD mouse models have been used to evaluate treatments for patients.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Oxidación-Reducción
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Modelos Animales de Enfermedad
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Ácidos Grasos
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Errores Innatos del Metabolismo Lipídico
Límite:
Animals
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Humans
Idioma:
En
Revista:
Mol Genet Metab
Asunto de la revista:
BIOLOGIA MOLECULAR
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BIOQUIMICA
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METABOLISMO
Año:
2024
Tipo del documento:
Article