International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis.
Autophagy
; 20(6): 1213-1246, 2024 Jun.
Article
en En
| MEDLINE
| ID: mdl-38442890
ABSTRACT
Macroautophagy/autophagy is a complex degradation process with a dual role in cell death that is influenced by the cell types that are involved and the stressors they are exposed to. Ferroptosis is an iron-dependent oxidative form of cell death characterized by unrestricted lipid peroxidation in the context of heterogeneous and plastic mechanisms. Recent studies have shed light on the involvement of specific types of autophagy (e.g. ferritinophagy, lipophagy, and clockophagy) in initiating or executing ferroptotic cell death through the selective degradation of anti-injury proteins or organelles. Conversely, other forms of selective autophagy (e.g. reticulophagy and lysophagy) enhance the cellular defense against ferroptotic damage. Dysregulated autophagy-dependent ferroptosis has implications for a diverse range of pathological conditions. This review aims to present an updated definition of autophagy-dependent ferroptosis, discuss influential substrates and receptors, outline experimental methods, and propose guidelines for interpreting the results.Abbreviation 3-MA3-methyladenine; 4HNE 4-hydroxynonenal; ACD accidentalcell death; ADF autophagy-dependentferroptosis; ARE antioxidant response element; BH2dihydrobiopterin; BH4 tetrahydrobiopterin; BMDMs bonemarrow-derived macrophages; CMA chaperone-mediated autophagy; CQchloroquine; DAMPs danger/damage-associated molecular patterns; EMT,epithelial-mesenchymal transition; EPR electronparamagnetic resonance; ER, endoplasmic reticulum; FRET Försterresonance energy transfer; GFP green fluorescent protein;GSH glutathione;IF immunofluorescence; IHC immunohistochemistry; IOP, intraocularpressure; IRI ischemia-reperfusion injury; LAA linoleamide alkyne;MDA malondialdehyde; PGSK Phen Green™ SK;RCD regulatedcell death; PUFAs polyunsaturated fatty acids; RFP red fluorescentprotein;ROS reactive oxygen species; TBA thiobarbituricacid; TBARS thiobarbituric acid reactive substances; TEMtransmission electron microscopy.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Autofagia
/
Ferroptosis
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Autophagy
Año:
2024
Tipo del documento:
Article
País de afiliación:
China