The metabolism of melanin synthesis-From melanocytes to melanoma.
Pigment Cell Melanoma Res
; 37(4): 438-452, 2024 07.
Article
en En
| MEDLINE
| ID: mdl-38445351
ABSTRACT
Melanin synthesis involves the successful coordination of metabolic pathways across multiple intracellular compartments including the melanosome, mitochondria, ER/Golgi, and cytoplasm. While pigment production offers a communal protection from UV damage, the process also requires anabolic and redox demands that must be carefully managed by melanocytes. In this report we provide an updated review on melanin metabolism, including recent data leveraging new techniques, and technologies in the field of metabolism. We also discuss the many aspects of melanin synthesis that intersect with metabolic pathways known to impact melanoma phenotypes and behavior. By reviewing the metabolism of melanin synthesis, we hope to highlight outstanding questions and opportunities for future research that could improve patient outcomes in pigmentary and oncologic disease settings.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Melaninas
/
Melanocitos
/
Melanoma
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Pigment Cell Melanoma Res
Asunto de la revista:
NEOPLASIAS
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos