Carboplatin desensitization - simplified 4-step 2-bag method.
J Oncol Pharm Pract
; 30(4): 759-766, 2024 Jun.
Article
en En
| MEDLINE
| ID: mdl-38470451
ABSTRACT
INTRODUCTION:
Our cancer program adopted a method for carboplatin desensitization (4-step 2-bag method) that administers the same intensity of drug exposure with a simplified approach to product management in comparison to a published protocol (4-step 4-bag method).METHODS:
The intensity of carboplatin administration for 11,000, 1100, 110, and 11 dilutions and concomitant fluid administration were compared for the 4-step 2-bag (bags A, B) and 4-step 4-bag (bags 1, 2, 3, 4) methods. Pharmacy preparation of bags A and B is described. A succinct overview of the desensitization procedure is provided. Important considerations germane to pharmacy practice are presented. Chart review of patients who underwent carboplatin desensitization with the 4-step 2-bag method between 7/13/2021 and 11/22/2023 was performed to demonstrate institutional use.RESULTS:
The 4-step 2-bag method delivers similar rates of drug intensity from start of desensitization to completion of the planned dose as the previously published 4-step 4-bag method. Accuracy of regimen-based dose administration is assured by infusion of bag B contents irrespective of infusion interruptions or rate changes necessitated by patient tolerance. Bag A provides the 11000 dilution in a pharmaceutically elegant manner using administration rates and volumes compatible with clinical practice.CONCLUSION:
The 4-step 2-bag method for carboplatin desensitization administers controlled drug titration corresponding to 11000, 1100, 110, and 11 dilutions for dose administration using two compounded admixture bags. Inaugural clinical use of the 4-step 2-bag method for carboplatin desensitization at our healthcare facility has proceeded with expected patient tolerance.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Carboplatino
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Desensibilización Inmunológica
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Antineoplásicos
Límite:
Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Oncol Pharm Pract
Asunto de la revista:
FARMACIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos