Incorporating PHI in decision making: external validation of the Rotterdam risk calculators for detection of prostate cancer.
World J Urol
; 42(1): 141, 2024 Mar 13.
Article
en En
| MEDLINE
| ID: mdl-38478041
ABSTRACT
PURPOSE:
External validation of existing risk calculators (RC) to assess the individualized risk of detecting prostate cancer (PCa) in prostate biopsies is needed to determine their clinical usefulness. The objective was to externally validate the Rotterdam Prostate Cancer RCs 3 and 4 (RPCRC-3/4) and that incorporating PHI (RPCRC-PHI) in a contemporary Spanish cohort.METHODS:
Multicenter prospective study that included patients suspicious of harboring PCa. Men who attended the urology consultation were tested for PHI before prostate biopsy. To evaluate the performance of the prediction models discrimination (receiver operating characteristic (ROC) curves), calibration and net benefit [decision curve analysis (DCA)] were calculated. These analyses were carried out for detection of any PCa and clinically significant (cs)PCa, defined as ISUP grade ≥ 2.RESULTS:
Among the 559 men included, 337 (60.28%) and 194 (34.7%) were diagnosed of PCa and csPCa, respectively. RPCRC-PHI had the best discrimination ability for detection of PCa and csPCa with AUCs of 0.85 (95%CI 0.82-0.88) and 0.82 (95%CI 0.78-0.85), respectively. Calibration plots showed that RPCRC-3/4 underestimates the risk of detecting PCa showing the need for recalibration. In DCA, RPCRC-PHI shows the highest net benefit compared to biopsy all men.CONCLUSIONS:
The RPCRC-PHI performed properly in a contemporary clinical setting, especially for prediction of csPCa.Palabras clave
Texto completo:
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Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Próstata
/
Antígeno Prostático Específico
Límite:
Humans
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Male
Idioma:
En
Revista:
World J Urol
/
World j. urol
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World journal of urology
Año:
2024
Tipo del documento:
Article
País de afiliación:
España