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Associations between brake and tire wear-related PM2.5 metal components, particulate oxidative stress potential, and autism spectrum disorder in Southern California.
O'Sharkey, Karl; Meng, Qi; Mitra, Sanjali; Paik, Seung-A; Liu, Jonathan; Shen, Jiaqi; Thompson, Laura K; Chow, Ting; Su, Jason; Cockburn, Myles; Weichenthal, Scott; Paulson, Susanne E; Jerrett, Michael; Ritz, Beate.
Afiliación
  • O'Sharkey K; Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Meng Q; Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Mitra S; Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Paik SA; Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Liu J; Department of Environmental Health Sciences, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Shen J; Department of Atmospheric & Oceanic Sciences, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Thompson LK; Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA 90032, USA.
  • Chow T; Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Su J; Department of Environmental Health Sciences, School of Public Health, University of California, Berkeley, Berkeley, CA 94720, USA.
  • Cockburn M; Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA 90032, USA.
  • Weichenthal S; Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Quebec H3A0G4, Canada.
  • Paulson SE; Department of Atmospheric & Oceanic Sciences, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Jerrett M; Department of Environmental Health Sciences, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Ritz B; Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Environmental Health Sciences, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: britz
Environ Int ; 185: 108573, 2024 Mar.
Article en En | MEDLINE | ID: mdl-38484609
ABSTRACT

BACKGROUND:

Air pollution is a global health concern, with fine particulate matter (PM2.5) constituents posing potential risks to human health, including children's neurodevelopment. Here we investigated associations between exposure during pregnancy and infancy to specific traffic-related PM2.5 components with Autism Spectrum Disorder (ASD) diagnosis.

METHODS:

For exposure assessment, we estimated PM2.5 components related to traffic exposure (Barium [Ba] as a marker of brake dust and Zinc [Zn] as a tire wear marker, Black Carbon [BC]) and oxidative stress potential (OSP) markers (Hydroxyl Radical [OPOH] formation, Dithiothreitol activity [OPDTT], reactive oxygen species [ROS]) modeled with land use regression with co-kriging based on an intensive air monitoring campaign. We assigned exposures to a cohort of 444,651 children born in Southern California between 2016 and 2019, among whom 11,466 ASD cases were diagnosed between 2018 and 2022, Odds ratios (ORs) and 95% confidence intervals (CIs) were obtained with logistic regression for single pollutant and PM2.5 mass co-adjusted models, also adjusting for sociodemographic characteristics.

RESULTS:

Among PM2.5 components, we found the strongest positive association with ASD for our brake wear marker Ba (ORper IQR = 1.29, 95 % CI 1.24, 1.34). This was followed by an increased risk for all PM2.5 oxidative stress potential markers; the strongest association was with ROS formation (ORper IQR = 1.22, 95 % CI 1.18, 1.25). PM2.5 mass was linked to ASD in Hispanic and Black children, but not White children, while traffic-related PM2.5 and OSP markers increased ASD risk across all groups. In neighborhoods with the lowest socioeconomic status (SES), associations with ASD were stronger for all examined pollutants compared to higher SES areas.

CONCLUSIONS:

Our findings suggest that brake wear-related PM2.5 and PM2.5 OSP are associated with ASD diagnosis in Southern California. These results suggest that strategies aimed at reducing the public health impacts of PM2.5 need to consider specific sources.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Contaminantes Atmosféricos / Contaminación del Aire / Trastorno del Espectro Autista Límite: Child / Female / Humans / Pregnancy País/Región como asunto: America do norte Idioma: En Revista: Environ Int Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Contaminantes Atmosféricos / Contaminación del Aire / Trastorno del Espectro Autista Límite: Child / Female / Humans / Pregnancy País/Región como asunto: America do norte Idioma: En Revista: Environ Int Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos