Light in a Heartbeat: Bond Scission by a Single Photon above 800 nm.
J Am Chem Soc
; 146(12): 8417-8424, 2024 03 27.
Article
en En
| MEDLINE
| ID: mdl-38499198
ABSTRACT
Photocages enable scientists to take full control over the activity of molecules using light as a biocompatible stimulus. Their emerging applications in photoactivated therapies call for efficient uncaging in the near-infrared (NIR) window, which represents a fundamental challenge. Here, we report synthetically accessible cyanine photocages that liberate alcohol, phenol, amine, and thiol payloads upon irradiation with NIR light up to 820 nm in aqueous media. The photocages display a unique chameleon-like behavior and operate via two distinct uncaging mechanisms photooxidation and heterolytic bond cleavage. The latter process constitutes the first example of a direct bond scission by a single photon ever observed in cyanine dyes or at wavelengths exceeding 800 nm. Modulation of the beating rates of human cardiomyocytes that we achieved by light-actuated release of adrenergic agonist etilefrine at submicromolar concentrations and low NIR light doses (â¼12 J cm-2) highlights the potential of these photocages in biology and medicine.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Fotones
Límite:
Humans
Idioma:
En
Revista:
J Am Chem Soc
Año:
2024
Tipo del documento:
Article
País de afiliación:
Suiza