Incidence of blood culture-related sepsis in neonates and antibiotics sensitivity of implicated organisms in a secondary healthcare facility in Ghana.
Ghana Med J
; 57(2): 134-140, 2023 Jun.
Article
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| MEDLINE
| ID: mdl-38504752
ABSTRACT
Objective:
We determined the incidence of blood culture-related sepsis, causative bacteria, and antibiotics sensitivity among newborn babies with suggestive signs of sepsis admitted at the Upper East Regional Hospital in Bolgatanga, Ghana.Design:
Prospective cross-sectional study.Setting:
Newborn Care Unit of the Upper East Regional Hospital, Bolgatanga.Participants:
Neonates admitted to the Newborn Care Unit from August 2019 to August 2020 with signs of sepsis. Main outcomemeasures:
Organisms isolated from blood cultures and sensitivity of isolated organisms to antibiotics.Results:
The study included two hundred and seventy-six (276) patients. Laboratory confirmed sepsis was 13.4% (37/276). Early onset sepsis was 3.3% (9/276), while late-onset sepsis was 10.1% (28/276). The most common clinical signs associated with positive culture cases were temperature instability (35.5%), poor feeding (14.5%), neonatal jaundice (11.3%), vomiting (9.7%), and respiratory distress (8.1%). Staphylococcus aureus and Staphylococcus epidermidis were the most common bacterial isolates (46% and 32%, respectively). There was no relationship between independent variables and blood culture confirmed sepsis. Antibiotics to which isolates were most resistant included flucloxacillin 4/4, penicillin 14/15, ampicillin 16/18, and tetracycline 23/28. Bacterial isolates were most sensitive to amikacin 16/16, levofloxacin 5/5, erythromycin 8/8, cefazolin 7/8, and ciprofloxacin 18/24.Conclusion:
Late-onset sepsis is a common sepsis category, and the implicated microorganisms are resistant to commonly prescribed antibiotics.Funding:
This work was funded by Upper East Regional Hospital, Bolgatanga.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Sepsis
/
Antibacterianos
Límite:
Humans
/
Newborn
País/Región como asunto:
Africa
Idioma:
En
Revista:
Ghana Med J
Año:
2023
Tipo del documento:
Article
País de afiliación:
Ghana