The Swiss Primary Hypersomnolence and Narcolepsy Cohort Study: feasibility of long-term monitoring with Fitbit smartwatches in central disorders of hypersomnolence and extraction of digital biomarkers in narcolepsy.
Sleep
; 47(9)2024 Sep 09.
Article
en En
| MEDLINE
| ID: mdl-38551123
ABSTRACT
The Swiss Primary Hypersomnolence and Narcolepsy Cohort Study (SPHYNCS) is a multicenter research initiative to identify new biomarkers in central disorders of hypersomnolence (CDH). Whereas narcolepsy type 1 (NT1) is well characterized, other CDH disorders lack precise biomarkers. In SPHYNCS, we utilized Fitbit smartwatches to monitor physical activity, heart rate, and sleep parameters over 1 year. We examined the feasibility of long-term ambulatory monitoring using the wearable device. We then explored digital biomarkers differentiating patients with NT1 from healthy controls (HC). A total of 115 participants received a Fitbit smartwatch. Using a adherence metric to evaluate the usability of the wearable device, we found an overall adherence rate of 80% over 1 year. We calculated daily physical activity, heart rate, and sleep parameters from 2 weeks of greatest adherence to compare NT1 (nâ
=â
20) and HC (nâ
=â
9) participants. Compared to controls, NT1 patients demonstrated findings consistent with increased sleep fragmentation, including significantly greater wake-after-sleep onset (pâ
=â
.007) and awakening index (pâ
=â
.025), as well as standard deviation of time in bed (pâ
=â
.044). Moreover, NT1 patients exhibited a significantly shorter REM latency (pâ
=â
.019), and sleep latency (pâ
=â
.001), as well as a lower peak heart rate (pâ
=â
.008), heart rate standard deviation (pâ
=â
.039) and high-intensity activity (pâ
=â
.009) compared to HC. This ongoing study demonstrates the feasibility of long-term monitoring with wearable technology in patients with CDH and potentially identifies a digital biomarker profile for NT1. While further validation is needed in larger datasets, these data suggest that long-term wearable technology may play a future role in diagnosing and managing narcolepsy.
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Texto completo:
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Base de datos:
MEDLINE
Asunto principal:
Biomarcadores
/
Estudios de Factibilidad
/
Dispositivos Electrónicos Vestibles
/
Narcolepsia
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
País/Región como asunto:
Europa
Idioma:
En
Revista:
Sleep
Año:
2024
Tipo del documento:
Article
País de afiliación:
Suiza