Compared to oxcarbazepine and carbamazepine, botulinum toxin type A is a useful therapeutic option for trigeminal neuralgia symptoms: A systematic review.
Clin Exp Dent Res
; 10(2): e882, 2024 Apr.
Article
en En
| MEDLINE
| ID: mdl-38558383
ABSTRACT
OBJECTIVES:
This review aimed to compare the effectiveness of three treatments BTX A, CBZ, and OXB, in managing trigeminal neuralgia (TN). MATERIAL ANDMETHODS:
We conducted a thorough search for research articles related to our issue using specific keywords on several databases, including Cochrane Central Register of Controlled Trials, Science Direct, Scopus, PubMed, Elsevier, Springer Journals, Ovid Medline, EBSCO, and Web of Science. Our focus was on publications from 1965 to 2023.RESULTS:
We retrieved 46 articles from the search and reviewed them carefully. Out of these, we selected 29 articles that met the inclusion criteria. Among the selected articles, 11 investigated the effects of CBZ and OXB, while 18 explored the impact of BTX A on the improvement of TN symptoms. The response rate ranged between 56% and 90.5% for CBZ and between 90.9% and 94% for OXB. The response rate for BTX A ranged between 51.4% and 100%. All these three treatments had a remarkable effect on the improvement of TN. Importantly, findings highlighted that side effects of CBZ and OXB could lead to treatment discontinuation in some cases, whereas BTX A's side effects have been minimal and less frequent.CONCLUSIONS:
Consequently, BTX A emerges as a promising alternative for TN treatment. However, additional clinical trials are necessary to validate this finding, and further research is required to establish a standardized protocol for administering BTX A in TN.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Neuralgia del Trigémino
/
Carbamazepina
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Toxinas Botulínicas Tipo A
/
Oxcarbazepina
Límite:
Humans
Idioma:
En
Revista:
Clin Exp Dent Res
Año:
2024
Tipo del documento:
Article
País de afiliación:
Irán