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Severe hemolysis, elevated liver enzymes, and low platelet syndrome requiring differentiation of thrombotic microangiopathy: Four cases from a nationwide survey in Japan.
Komatsu, Reina; Mimura, Kazuya; Matsuyama, Tatsuya; Kawanishi, Yoko; Nakamura, Hitomi; Tomimatsu, Takuji; Endo, Masayuki; Kimura, Tadashi.
Afiliación
  • Komatsu R; Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
  • Mimura K; Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
  • Matsuyama T; Department of Obstetrics and Gynecology, Osaka Saiseikai Nakatsu Hospital, Osaka-shi, Osaka, Japan.
  • Kawanishi Y; Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
  • Nakamura H; Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
  • Tomimatsu T; Department of Nursing, Faculty of Global Nursing, Otemae University, Osaka-shi, Osaka, Japan.
  • Endo M; Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
  • Kimura T; Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
J Obstet Gynaecol Res ; 50(7): 1258-1262, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38589336
ABSTRACT
Severe cases of hemolysis, elevated liver enzymes, and low platelet (HELLP) syndrome requiring plasma exchange or dialysis should be differentiated from other thrombotic microangiopathy (TMA) and treated appropriately. To evaluate the prevalence and clinical characteristics of such cases in Japan, a questionnaire-based survey was conducted among obstetricians who are members of the Perinatal Research Network Group in Japan. There were a total of 335 cases of HELLP syndrome over a 3-year period in the 48 facilities that responded to the survey. Four patients required plasma exchange or dialysis, of which two were diagnosed with atypical hemolytic uremic syndrome and two with TMA secondary to systemic lupus erythematosus. Although such severe HELLP syndrome is rare, identifying the clinical features and making accurate differential diagnosis are critical for optimal clinical outcomes for mothers and neonates.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Síndrome HELLP / Microangiopatías Trombóticas Límite: Adult / Female / Humans / Pregnancy País/Región como asunto: Asia Idioma: En Revista: J Obstet Gynaecol Res Asunto de la revista: GINECOLOGIA / OBSTETRICIA Año: 2024 Tipo del documento: Article País de afiliación: Japón

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Síndrome HELLP / Microangiopatías Trombóticas Límite: Adult / Female / Humans / Pregnancy País/Región como asunto: Asia Idioma: En Revista: J Obstet Gynaecol Res Asunto de la revista: GINECOLOGIA / OBSTETRICIA Año: 2024 Tipo del documento: Article País de afiliación: Japón