A Technology-Assisted Web Application for Consumer Access to a Nonprescription Statin Medication.
J Am Coll Cardiol
; 83(21): 2080-2088, 2024 May 28.
Article
en En
| MEDLINE
| ID: mdl-38599257
ABSTRACT
BACKGROUND:
Although statins reduce adverse cardiovascular outcomes, less than one-half of eligible patients receive treatment. A nonprescription statin has the potential to improve access to statins.OBJECTIVES:
This study sought to assess concordance between clinician and consumer assessment of eligibility for nonprescription statin treatment using a technology assisted self-selection Web application (Web App) and evaluate effect on low-density lipoprotein cholesterol (LDL-C) levels.METHODS:
This study was a prospective actual use 6-month study to evaluate use of a Web App to qualify participants without a medical background for a moderate-intensity statin based on current guidelines. Participants entered demographic information, cholesterol values, blood pressure, and concomitant medications into the Web App, resulting in 3 possibleoutcomes:
"do not use," "ask a doctor," and "OK to use."RESULTS:
The study included 1,196 participants, with a median age of 63 years (Q1-Q3 57-68 years); 39.6% were women, 79.3% were White, 11.7% were Black, and 4.1% had limited literacy. Mean LDL-C was 139.6 ± 28.3 mg/dL and the median calculated 10-year risk of atherosclerotic cardiovascular disease was 10.1% (Q1-Q3 7.3%-14.0%). Initial Web App self-selection resulted in an outcome concordant with clinician assessment in 90.7% (95% CI 88.9%-92.3%) of participants, and 98.1% (95% CI 97.1%-98.8%) had a concordant final use outcome during treatment. Mean percent change in LDL-C was -35.5% (95% CI -36.6% to -34.3%). Serious adverse events occurred in 27 (2.3%) participants, none related to the study drug.CONCLUSIONS:
In this actual use study, a technology-assisted Web App allowed >90% of consumers to correctly self-select for statin use and achieve clinically important LDL-C reductions. (Technology-Assisted Cholesterol Trial in Consumers [TACTiC]; NCT04964544).Palabras clave
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Base de datos:
MEDLINE
Asunto principal:
Inhibidores de Hidroximetilglutaril-CoA Reductasas
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Internet
Límite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Am Coll Cardiol
Año:
2024
Tipo del documento:
Article