Helminth-induced impairment of humoral immunity differently contribute to their anti-arthritic effects in mice: Comparison of Schistosoma mansoni and Trichinella spiralis.
Exp Parasitol
; 261: 108752, 2024 Jun.
Article
en En
| MEDLINE
| ID: mdl-38604301
ABSTRACT
AIMS:
We have previously reported reduction of anti-type II collagen (IIC) IgG levels in collagen-induced arthritis (CIA) by Schistosoma mansoni (Sm) and Trichinella spiralis (Ts). To clarify the contribution of the impairment of humoral immunity to their anti-arthritic activities, we herein investigated the relationship between anti-IIC IgG levels and arthritic swelling in Sm- or Ts-infected mice. METHODS ANDRESULTS:
Male DBA/1J mice were infected with Sm cercariae or Ts muscle larvae prior to the IIC immunization. In the Sm-infected mice, paw swelling and anti-IIC IgG levels were continuously lower than those of non-infected control group. In contrast, arthritic swelling in the Ts-infected mice only decreased in the early phase of CIA progression, despite the continued impairment of anti-IIC IgG production throughout the experimental period. Correlation coefficients between residual paw swelling and anti-IIC IgG titers were similar or higher in the Sm group than in the control group, but were similar or lower in the Ts group than in the control group.CONCLUSION:
The down-modulations of anti-IIC IgG levels by the two parasitic infections and the correlation analyses suggest that the anti-arthritic activity of Sm was primarily attributed to the modulation of IgG-independent arthritogenic mechanisms and secondarily to the impairment of anti-IIC IgG production. In contrast, Ts could alleviate CIA mainly via the impairment of antibody production.Palabras clave
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Base de datos:
MEDLINE
Asunto principal:
Artritis Experimental
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Schistosoma mansoni
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Triquinelosis
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Esquistosomiasis mansoni
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Inmunoglobulina G
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Trichinella spiralis
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Inmunidad Humoral
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Ratones Endogámicos DBA
Límite:
Animals
Idioma:
En
Revista:
Exp Parasitol
Año:
2024
Tipo del documento:
Article