Progress on the relationship between tumor suppressor PDCD4 and diseases based on the analysis of structural characteristics.
Yi Chuan
; 46(4): 290-305, 2024 Apr 20.
Article
en En
| MEDLINE
| ID: mdl-38632092
ABSTRACT
The tumor suppressor programmed cell death 4 (PDCD4) is downregulated in various tumor tissues indicating poor prognosis. PDCD4 is the first protein found to resist tumor transformation, invasion, and metastasis by inhibiting translation. The functions of PDCD4 dependent on its structures are affected by extracellular signals. It regulates tumor-related proteins through a variety of mechanisms, especially involved in two major signaling pathways, PI3K-Akt-mTOR and MAPK. By analyzing the relationship between the structures, functions and diseases of PDCD4, this review summarizes the roles of PDCD4 in several physiological processes and diseases such as apoptosis, autophagy, tumor, and inflammation in recent years, thereby providing insights for the study of the signaling pathways of PDCD4 and related proteins and the treatment of diseases targeting them.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Proteínas de Unión al ARN
/
Fosfatidilinositol 3-Quinasas
/
Proteínas Reguladoras de la Apoptosis
Límite:
Humans
Idioma:
En
Revista:
Yi Chuan
Asunto de la revista:
GENETICA
Año:
2024
Tipo del documento:
Article
País de afiliación:
China