Protective effects of COVID-19 vaccination in splenectomized patients with immune thrombocytopenia.
Br J Haematol
; 204(6): 2217-2221, 2024 Jun.
Article
en En
| MEDLINE
| ID: mdl-38632670
ABSTRACT
Splenectomy is an effective treatment for immune thrombocytopenia (ITP). The effect of COVID-19 vaccination on splenectomized patients with ITP during the COVID-19 pandemic has not been reported. Therefore, this study aimed to investigate the effect of COVID-19 vaccination on clinical outcomes in these patients. This was a longitudinal study of splenectomized patients with ITP. A total of 191 splenectomized patients were included in this study. After a median follow-up of 114 months, 146 (76.4%) patients had a sustained response to splenectomy. During COVID-19 infection, vaccinated patients showed a lower risk of severe infections (odds ratio [OR], 0.13; 95% confidence interval [CI] 0.05-0.36; p < 0.001), hospitalization (OR, 0.13; 95% CI, 0.04-0.48; p = 0.002), and ITP exacerbation (OR, 0.16; 95% CI, 0.04-0.67; p = 0.012). These findings indicate that COVID-19 vaccination plays a protective role in splenectomized patients with ITP.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Esplenectomía
/
Púrpura Trombocitopénica Idiopática
/
Vacunas contra la COVID-19
/
SARS-CoV-2
/
COVID-19
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Br J Haematol
/
Br. j. haematol
/
British journal of haematology
Año:
2024
Tipo del documento:
Article
País de afiliación:
China