Stimulating thyrotropin receptor antibodies in early pregnancy.
Clin Chem Lab Med
; 2024 Apr 19.
Article
en En
| MEDLINE
| ID: mdl-38634229
ABSTRACT
OBJECTIVES:
Thyrotropin-receptor antibodies (TRAb) are used to diagnose Graves' hyperthyroidism in pregnant women. Bioassays provide a measure of thyrotropin-receptor stimulatory antibodies (TSI) specifically. The objective was to measure TSI in pregnant women for establishment of a pregnancy-specific cut-off and comparison with immunoassay measurements of TRAb.METHODS:
The retrospective Danish study was performed within the North Denmark Region Pregnancy Cohort (2011-2015) that includes stored biobank samples from early pregnancy (median week 10) with immunoassay measurements of thyroid function parameters and TRAb. TSI were measured in the same samples using the Turbo TSI bioassay (Quidel/Ortho-Clinical Diagnostics) with a recommended cut-off of 0.0241â¯IU/L in non-pregnant adults. A pregnancy-specific TSI cut-off (95-percentile) was established using Regression on Order Statistics.RESULTS:
The established TSI cut-off was 0.0418â¯IU/L (95â¯% CI 0.0417-0.0419). Among women with early pregnancy hyperthyroidism (n=438), 43 women (9.8â¯%) were TSI positive using the established cut-off, and these women had lower TSH (median 0.008â¯mIU/L) compared to women with TSI levels below 0.0241 (median TSH 0.040â¯mIU/L) or in the range from 0.0241 to 0.0418 (median TSH 0.033â¯mIU/L). Among the 438 women with early pregnancy hyperthyroidism, 22 women were positive for TSI and TRAb, 388 were negative for both, and 28 women were positive for either TSI or TRAb.CONCLUSIONS:
This is the first study on TSI measurements in a large cohort of early pregnant women. A pregnancy-specific cut-off for TSI was established and agreement in the classification with immunoassay measurements of TRAb was seen in 94â¯% of cases.
Texto completo:
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Base de datos:
MEDLINE
Idioma:
En
Revista:
Clin Chem Lab Med
Asunto de la revista:
QUIMICA CLINICA
/
TECNICAS E PROCEDIMENTOS DE LABORATORIO
Año:
2024
Tipo del documento:
Article
País de afiliación:
Dinamarca