Diet switch pre-vaccination improves immune response and metabolic status in formerly obese mice.
Nat Microbiol
; 9(6): 1593-1606, 2024 Jun.
Article
en En
| MEDLINE
| ID: mdl-38637722
ABSTRACT
Metabolic disease is epidemiologically linked to severe complications upon influenza virus infection, thus vaccination is a priority in this high-risk population. Yet, vaccine responses are less effective in these same hosts. Here we examined how the timing of diet switching from a high-fat diet to a control diet affected influenza vaccine efficacy in diet-induced obese mice. Our results demonstrate that the systemic meta-inflammation generated by high-fat diet exposure limited T cell maturation to the memory compartment at the time of vaccination, impacting the recall of effector memory T cells upon viral challenge. This was not improved with a diet switch post-vaccination. However, the metabolic dysfunction of T cells was reversed if weight loss occurred 4 weeks before vaccination, restoring a functional recall response. This corresponded with changes in the systemic obesity-related biomarkers leptin and adiponectin, highlighting the systemic and specific effects of diet on influenza vaccine immunogenicity.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Vacunas contra la Influenza
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Infecciones por Orthomyxoviridae
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Dieta Alta en Grasa
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Obesidad
Límite:
Animals
Idioma:
En
Revista:
Nat Microbiol
/
Nat. microbiol
/
Nature microbiology
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos