Brain stimulation over the left DLPFC enhances motivation for effortful rewards in patients with major depressive disorder.
J Affect Disord
; 356: 414-423, 2024 Jul 01.
Article
en En
| MEDLINE
| ID: mdl-38640975
ABSTRACT
BACKGROUND:
Amotivation is a typical feature in major depressive disorder (MDD), which produces reduced willingness to exert effort. The dorsolateral prefrontal cortex (DLPFC) is a crucial structure in goal-directed actions and therefore is a potential target in modulating effortful motivation. However, it remains unclear whether the intervention is effective for patients with MDD.METHODS:
We employed transcranial magnetic stimulation (TMS), computational modelling and event-related potentials (ERPs) to reveal the causal relationship between the left DLPFC and motivation for effortful rewards in MDD. Fifty patients underwent both active and sham TMS sessions, each followed by performing an Effort-Expenditure for Rewards Task, during which participants chose and implemented between low-effort/low-reward and high-effort/high-reward options.RESULTS:
The patients showed increased willingness to exert effort for rewards during the DLPFC facilitated session, compared with the sham session. They also had a trend in larger P3 amplitude for motivated attention toward chosen options, larger CNV during preparing for effort exertion, and larger SPN during anticipating a high reward. Besides, while behavior indexes for effortful choices were negatively related to depression severity in the sham session, this correlation was weakened in the active stimulation session.CONCLUSIONS:
These findings provide behavioral, computational, and neural evidence for the left DLPFC on effortful motivation for rewards. Facilitated DLPFC improves motor preparation and value anticipation after making decisions especially for highly effortful rewards in MDD. Facilitated DLPFC also has a potential function in enhancing motivated attention during cost-benefit trade-off. This neuromodulation effect provides a potential treatment for improving motivation in clinics.Palabras clave
Texto completo:
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Base de datos:
MEDLINE
Asunto principal:
Recompensa
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Trastorno Depresivo Mayor
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Estimulación Magnética Transcraneal
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Corteza Prefontal Dorsolateral
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Motivación
Límite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Affect Disord
Año:
2024
Tipo del documento:
Article
País de afiliación:
China