Immune checkpoint inhibitor for different age patients with NSCLC in efficacy: A systematic review and meta-analysis.
Asian J Surg
; 2024 Apr 18.
Article
en En
| MEDLINE
| ID: mdl-38641539
ABSTRACT
OBJECTIVE:
This article is a Meta-analysis aiming to systematically evaluate the difference in efficacy of immune checkpoint inhibitor in patients with non-small cell lung cancer (NSCLC) by age.METHODS:
We performed a Meta-analysis of published randomized controlled trials concerning for patients with NSCLC by age. We compared overall survival among three groups (age <65 years, age 65-75 years, age ≥75 years). Hazard ratios (HRs) and 95% confidence intervals (CIs) were collected and pooled.RESULTS:
A total of 10,291 patients from 17 RCTs were included. In the group under age 65 years, immune checkpoint inhibitor can significantly prolong the overall survival of patients with NSCLC (HR = 0.73, 95% CI 0.66â¼0.81, P < 0.00001). In the age 65-75 years group, immune checkpoint inhibitors prolonged overall survival in patients with NSCLC (HR = 0.78, 95% CI0.71â¼0.84, P < 0.00001). However, it has no significant effect on the overall survival of NSCLC patients (HR = 0.88, 95% CI0.72â¼1.08, P > 0.05) in the group older than 75 years.CONCLUSIONS:
Immune checkpoint inhibitors prolonged the overall survival of NSCLC patients in the age <65 years group and the age 65-75 years group, but in the age ≥75 years group, there was no significant effect on overall survival. This may be related to innate immune and adaptive immune dysregulation due to "immunosenescence" in older patients.
Texto completo:
1
Base de datos:
MEDLINE
Idioma:
En
Revista:
Asian J Surg
Año:
2024
Tipo del documento:
Article
País de afiliación:
China