Association of cardiac biomarkers with long-term cardiovascular events in a community cohort.
Biomarkers
; 29(4): 161-170, 2024 Jun.
Article
en En
| MEDLINE
| ID: mdl-38666319
ABSTRACT
MATERIALS AND METHODS:
The study assessed major adverse cardiac events (MACE) (myocardial infarction, coronary artery bypass graft, percutaneous intervention, stroke, and death. Cox proportional hazards models assessed apolipoprotein AI (ApoA1), apolipoprotein B (ApoB), ceramide score, cystatin C, galectin-3 (Gal3), LDL-C, Non-HDL-C, total cholesterol (TC), N-terminal B-type natriuretic peptide (NT proBNP), high-sensitivity cardiac troponin (HscTnI) and soluble interleukin 1 receptor-like 1. In adjusted models, Ceramide score was defined by from N-palmitoyl-sphingosine [Cer(160)], N-stearoyl-sphingosine [Cer(180)], N-nervonoyl-sphingosine [Cer(241)] and N-lignoceroyl-sphingosine [Cer(240)]. Multi-biomarker models were compared with C-statistics and Integrated Discrimination Index (IDI).RESULTS:
A total of 1131 patients were included. Adjusted NT proBNP per 1 SD resulted in a 31% increased risk of MACE/death (HR = 1.31) and a 31% increased risk for stroke/MI (HR = 1.31). Adjusted Ceramide per 1 SD showed a 13% increased risk of MACE/death (HR = 1.13) and a 29% increased risk for stroke/MI (HR = 1.29). These markers added to clinical factors for both MACE/death (p = 0.003) and stroke/MI (p = 0.034). HscTnI was not a predictor of outcomes when added to the models.DISCUSSION:
Ceramide score and NT proBNP improve the prediction of MACE and stroke/MI in a community primary prevention cohort.
In a community cohort, where a wide range of biomarkers were evaluated, Ceramide score provided additive value over traditional cardiac risk factors alone for predicting stroke/MI. NT ProBNP provided additive value in prediction of MACE/death. Other biomarkers failed to improve the discrimination of these models.
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Base de datos:
MEDLINE
Asunto principal:
Fragmentos de Péptidos
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Biomarcadores
Límite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Biomarkers
Asunto de la revista:
BIOQUIMICA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos