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Total Synthesis of Lissodendoric Acid A.
Ippoliti, Francesca M; Wonilowicz, Laura G; Adamson, Nathan J; Darzi, Evan R; Donaldson, Joyann S; Nasrallah, Daniel J; Mehta, Milauni M; Kelleghan, Andrew V; Houk, K N; Garg, Neil K.
Afiliación
  • Ippoliti FM; Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Wonilowicz LG; Department of Chemistry, Hamline University, St. Paul, Minnesota, 55104, USA.
  • Adamson NJ; Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Darzi ER; Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Donaldson JS; Department of Discovery Chemistry, Genentech, Inc., South San Francisco, CA 94080, USA.
  • Nasrallah DJ; Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Mehta MM; ElectraTect, Inc., Phoenix, AZ 85004, USA.
  • Kelleghan AV; Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Houk KN; Pfizer Oncology Medicinal Chemistry, San Diego, CA 92121, USA.
  • Garg NK; Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Angew Chem Int Ed Engl ; 63(32): e202406676, 2024 08 05.
Article en En | MEDLINE | ID: mdl-38695853
ABSTRACT
We describe a full account of our synthetic strategy leading to the first total synthesis of the manzamine alkaloid lissodendoric acid A . These efforts demonstrate that strained cyclic allenes are valuable synthetic building blocks and can be employed efficiently in total synthesis.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Alcaloides Idioma: En Revista: Angew Chem Int Ed Engl Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Alcaloides Idioma: En Revista: Angew Chem Int Ed Engl Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos