Cancer stem-like cells in uveal melanoma: novel insights and therapeutic implications.
Biochim Biophys Acta Rev Cancer
; 1879(3): 189104, 2024 May.
Article
en En
| MEDLINE
| ID: mdl-38701937
ABSTRACT
Uveal melanoma (UM) is the most common primary ocular tumor in the adult population. Even though these primary tumors are successfully treated in 90% of cases, almost 50% of patients ultimately develop metastasis, mainly in the liver, via hematological dissemination, with a median survival spanning from 6 to 12 months after diagnosis. In this context, chemotherapy regimens and molecular targeted therapies have demonstrated poor response rates and failed to improve survival. Among the multiple reasons for therapy failure, the presence of cancer stem-like cells (CSCs) represents the main cause of resistance to anticancer therapies. In the last few years, the existence of CSCs in UM has been demonstrated both in preclinical and clinical studies, and new molecular pathways and mechanisms have been described for this subpopulation of UM cells. Here, we will discuss the state of the art of CSC biology and their potential exploitation as therapeutic target in UM.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Células Madre Neoplásicas
/
Neoplasias de la Úvea
/
Melanoma
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Biochim Biophys Acta Rev Cancer
Año:
2024
Tipo del documento:
Article
País de afiliación:
Italia