Neuroimmune modulation by tryptophan derivatives in neurological and inflammatory disorders.
Eur J Cell Biol
; 103(2): 151418, 2024 Jun.
Article
en En
| MEDLINE
| ID: mdl-38729083
ABSTRACT
The nervous and immune systems are highly developed, and each performs specialized physiological functions. However, they work together, and their dysfunction is associated with various diseases. Specialized molecules, such as neurotransmitters, cytokines, and more general metabolites, are essential for the appropriate regulation of both systems. Tryptophan, an essential amino acid, is converted into functional molecules such as serotonin and kynurenine, both of which play important roles in the nervous and immune systems. The role of kynurenine metabolites in neurodegenerative and psychiatric diseases has recently received particular attention. Recently, we found that hyperactivity of the kynurenine pathway is a critical risk factor for septic shock. In this review, we first outline neuroimmune interactions and tryptophan derivatives and then summarized the changes in tryptophan metabolism in neurological disorders. Finally, we discuss the potential of tryptophan derivatives as therapeutic targets for neuroimmune disorders.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Triptófano
/
Neuroinmunomodulación
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Eur J Cell Biol
Año:
2024
Tipo del documento:
Article
País de afiliación:
Japón