Virus-specific antibody secreting cells reside in the peritoneal cavity and systemic immune sites of Atlantic salmon (Salmo salar) challenged intraperitoneally with salmonid alphavirus.
Dev Comp Immunol
; 157: 105193, 2024 Aug.
Article
en En
| MEDLINE
| ID: mdl-38729458
ABSTRACT
The development and persistence of antibody secreting cells (ASC) after antigenic challenge remain inadequately understood in teleosts. In this study, intraperitoneal (ip) injection of Atlantic salmon (Salmo salar) with salmonid alphavirus (WtSAV3) increased the total ASC response, peaking 3-6 weeks post injection (wpi) locally in the peritoneal cavity (PerC) and in systemic lymphoid tissues, while at 13 wpi the response was only elevated in PerC. At the same time point a specific ASC response was induced by WtSAV3 in PerC and systemic tissues, with the highest frequency in PerC, suggesting a local role. Inactivated SAV (InSAV1) induced comparatively lower ASC responses in all sites, and specific serum antibodies were only induced by WtSAV3 and not by InSAV1. An InSAV1 boost did not increase these responses. Expression of immune marker genes implies a role for PerC adipose tissue in the PerC immune response. Overall, the study suggests the Atlantic salmon PerC as a secondary immune site and an ASC survival niche.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Cavidad Peritoneal
/
Infecciones por Alphavirus
/
Alphavirus
/
Salmo salar
/
Enfermedades de los Peces
/
Anticuerpos Antivirales
/
Células Productoras de Anticuerpos
Límite:
Animals
Idioma:
En
Revista:
Dev Comp Immunol
Año:
2024
Tipo del documento:
Article
País de afiliación:
Noruega