Potential of TSPO radioligands: Bridging brain tumor diagnostics to the peripheries.
Biochimie
; 224: 114-119, 2024 Sep.
Article
en En
| MEDLINE
| ID: mdl-38734123
ABSTRACT
Translocator protein (TSPO) is involved in several cellular mechanisms such as steroidogenesis, immunomodulation, cell proliferation and differentiation. Overexpressed in several neurodegenerative diseases and brain cancer, TSPO radioligands have been developed over the last 20 years in positron emission tomography (PET) imaging. Recently, TSPO radioligands have extended beyond their initial application due to their specific binding to activated macrophages, making them a compelling biomarker for deciphering the intricacies of the tumor microenvironment (TME). In this review, we synthesized recent progress from the evaluation of TSPO-specific PET tracers in various peripheral tumor models and highlighted the hurdles and limitations associated with heterogeneous uptake in healthy tissue and tumor regions to achieve the clinical development of such a radiotracer.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Encefálicas
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Receptores de GABA
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Tomografía de Emisión de Positrones
Límite:
Animals
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Humans
Idioma:
En
Revista:
Biochimie
Año:
2024
Tipo del documento:
Article
País de afiliación:
Francia