Sarcoidosis immunopathogenesis - a new concept of maladaptive trained immunity.
Trends Immunol
; 45(6): 406-418, 2024 Jun.
Article
en En
| MEDLINE
| ID: mdl-38796404
ABSTRACT
Sarcoidosis is a chronic immune disease of unknown origin for which we still lack an immunological framework unifying causal agents, host factors, and natural history of disease. Here, we discuss the initial triggers of disease, and how myeloid cells drive granuloma formation and contribute to immunopathogenesis. We highlight recent advances in our understanding of innate immune memory and propose the hypothesis that maladaptive innate immune training connects previous environmental exposure to granuloma maintenance and expansion. Lastly, we consider how this hypothesis may open novel therapeutic avenues, while corticosteroids remain the front-line treatment.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Sarcoidosis
/
Inmunidad Innata
/
Memoria Inmunológica
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Immunol
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2024
Tipo del documento:
Article