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Copper-Catalyzed Asymmetric Kinugasa/Michael Addition Cascade Reactions for the Synthesis of Chiral Spiro ß-Lactams.
Ao, Yunlin; Ma, Haowen; Gan, Binghan; Wang, Wenjing; Zhang, Jiehao; Zhou, Wei; Zhang, Xiaoqi; Cai, Qian.
Afiliación
  • Ao Y; College of Pharmacy, Jinan University, No. 601 Huangpu Avenue West, Guangzhou, 510632, P. R. China.
  • Ma H; College of Pharmacy, Jinan University, No. 601 Huangpu Avenue West, Guangzhou, 510632, P. R. China.
  • Gan B; College of Pharmacy, Jinan University, No. 601 Huangpu Avenue West, Guangzhou, 510632, P. R. China.
  • Wang W; College of Pharmacy, Jinan University, No. 601 Huangpu Avenue West, Guangzhou, 510632, P. R. China.
  • Zhang J; College of Pharmacy, Jinan University, No. 601 Huangpu Avenue West, Guangzhou, 510632, P. R. China.
  • Zhou W; College of Pharmacy, Jinan University, No. 601 Huangpu Avenue West, Guangzhou, 510632, P. R. China.
  • Zhang X; College of Pharmacy, Jinan University, No. 601 Huangpu Avenue West, Guangzhou, 510632, P. R. China.
  • Cai Q; College of Pharmacy, Jinan University, No. 601 Huangpu Avenue West, Guangzhou, 510632, P. R. China.
Org Lett ; 26(22): 4761-4766, 2024 Jun 07.
Article en En | MEDLINE | ID: mdl-38809099
ABSTRACT
A mild copper-catalyzed asymmetric Kinugasa/Michael addition cascade process is developed. The reaction of α, ß-unsaturated ester-tethered propiolamides with nitrones provides an efficient protocol for the construction of functionalized chiral 2,6-diazaspiro[3.4]octane-1,5-dione products in satisfactory yields and with high enantio- and diastereoselectivities.
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Texto completo: 1 Base de datos: MEDLINE Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2024 Tipo del documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de datos: MEDLINE Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2024 Tipo del documento: Article