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Diabetes mellitus as a risk factor for severe dengue fever and West Nile fever: A meta-analysis.
Lu, Hong-Zheng; Xie, Yu-Zhuang; Gao, Chen; Wang, Ying; Liu, Ting-Ting; Wu, Xing-Zhe; Dai, Fang; Wang, Duo-Quan; Deng, Sheng-Qun.
Afiliación
  • Lu HZ; Department of Pathogen Biology, Anhui Province Key Laboratory of Zoonoses, the Key Laboratory of Zoonoses of High Institutions in Anhui, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.
  • Xie YZ; Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui China.
  • Gao C; Department of Pathogen Biology, Anhui Province Key Laboratory of Zoonoses, the Key Laboratory of Zoonoses of High Institutions in Anhui, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.
  • Wang Y; Department of Pathogen Biology, Anhui Province Key Laboratory of Zoonoses, the Key Laboratory of Zoonoses of High Institutions in Anhui, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.
  • Liu TT; Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui China.
  • Wu XZ; Department of Tropical Medicine, College of Military Preventive Medicine, Army Medical University, Chongqing, China.
  • Dai F; Department of Tropical Medicine, College of Military Preventive Medicine, Army Medical University, Chongqing, China.
  • Wang DQ; Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
  • Deng SQ; Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
PLoS Negl Trop Dis ; 18(5): e0012217, 2024 May.
Article en En | MEDLINE | ID: mdl-38820529
ABSTRACT

BACKGROUND:

Dengue fever (DF) and West Nile fever (WNF) have become endemic worldwide in the last two decades. Studies suggest that individuals with diabetes mellitus (DM) are at a higher risk of developing severe complications from these diseases. Identifying the factors associated with a severe clinical presentation is crucial, as prompt treatment is essential to prevent complications and fatalities. This article aims to summarize and assess the published evidence regarding the link between DM and the risk of severe clinical manifestations in cases of DF and WNF. METHODOLOGY/PRINCIPAL

FINDINGS:

A systematic search was conducted using the PubMed and Web of Science databases. 27 studies (19 on DF, 8 on WNF) involving 342,873 laboratory-confirmed patients were included in the analysis. The analysis showed that a diagnosis of DM was associated with an increased risk for severe clinical presentations of both DF (OR 3.39; 95% CI 2.46, 4.68) and WNF (OR 2.89; 95% CI 1.89, 4.41). DM also significantly increased the risk of death from both diseases (DF OR 1.95; 95% CI 1.09, 3.52; WNF OR 1.74; 95% CI 1.40, 2.17). CONCLUSIONS/

SIGNIFICANCE:

This study provides strong evidence supporting the association between DM and an increased risk of severe clinical manifestations in cases of DF and WNF. Diabetic individuals in DF or WNF endemic areas should be closely monitored when presenting with febrile symptoms due to their higher susceptibility to severe disease. Early detection and appropriate management strategies are crucial in reducing the morbidity and mortality rates associated with DF and WNF in diabetic patients. Tailored care and targeted public health interventions are needed to address this at-risk population. Further research is required to understand the underlying mechanisms and develop effective preventive and therapeutic approaches.
Asunto(s)

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Fiebre del Nilo Occidental Límite: Humans Idioma: En Revista: PLoS Negl Trop Dis Asunto de la revista: MEDICINA TROPICAL Año: 2024 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Fiebre del Nilo Occidental Límite: Humans Idioma: En Revista: PLoS Negl Trop Dis Asunto de la revista: MEDICINA TROPICAL Año: 2024 Tipo del documento: Article País de afiliación: China