Effects and safety of high-frequency rTMS in subacute ischemic stroke patients.
J Neurol Sci
; 462: 123069, 2024 Jul 15.
Article
en En
| MEDLINE
| ID: mdl-38824817
ABSTRACT
OBJECTIVE:
Although high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) has shown benefits in chronic stroke, its application in subacute ischemic stroke remains underexplored. This study aims to investigate the effects and safety of lesion-side HF-rTMS in subacute ischemic stroke.METHODS:
Prospective lesion-side HF-rTMS was conducted on consecutive ischemic stroke patients within 3 days of onset from February 2019 to June 2022. Inclusion criteria required persistent paralysis (NIHSS score ≥ 1 for at least 7 days). Exclusion criteria comprised cortical infarction, disturbance of consciousness, and age over 80 years. A conventional rehabilitation group meeting the same criteria from June 2015 to January 2019 served as a comparison. We compared the two groups regarding clinical background and outcome. We also evaluated incidence of epilepsy and exacerbation of the NIHSS score in the rTMS group.RESULTS:
Seventy-eight patients participated, with 50% in the HF-rTMS group. Median time from onset to HF-rTMS initiation was 9 (IQR 7-12) days. A favorable outcome (modified Rankin Scale score 0-2) at 3 months was more frequent in the rTMS group (80% vs. 44%, p = 0.002). HF-rTMS was independently associated with a favorable outcome at 3 months (OR = 5.60, 95% CI = 1.53-20.50, p = 0.009). No cases of epilepsy or exacerbation of NIHSS score were observed.CONCLUSIONS:
HF-rTMS demonstrates potential effectiveness and safety in subacute ischemic stroke patients.Palabras clave
Texto completo:
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Base de datos:
MEDLINE
Asunto principal:
Estimulación Magnética Transcraneal
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Accidente Cerebrovascular Isquémico
Límite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Neurol Sci
Año:
2024
Tipo del documento:
Article