Nuclear receptor Nur77 and Yin-Yang 1 synergistically increase mitochondrial abundance and activity in macrophages.
FEBS Lett
; 598(14): 1715-1729, 2024 Jul.
Article
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| MEDLINE
| ID: mdl-38825601
ABSTRACT
Mitochondrial biogenesis requires precise regulation of both mitochondrial-encoded and nuclear-encoded genes. Nuclear receptor Nur77 is known to regulate mitochondrial metabolism in macrophages and skeletal muscle. Here, we compared genome-wide Nur77 binding site and target gene expression in these two cell types, which revealed conserved regulation of mitochondrial genes and enrichment of motifs for the transcription factor Yin-Yang 1 (YY1). We show that Nur77 and YY1 interact, that YY1 increases Nur77 activity, and that their binding sites are co-enriched at mitochondrial ribosomal protein gene loci in macrophages. Nur77 and YY1 co-expression synergistically increases Mrpl1 expression as well as mitochondrial abundance and activity in macrophages but not skeletal muscle. As such, we identify a macrophage-specific Nur77-YY1 interaction that enhances mitochondrial metabolism.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Factor de Transcripción YY1
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Miembro 1 del Grupo A de la Subfamilia 4 de Receptores Nucleares
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Macrófagos
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Mitocondrias
Límite:
Animals
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Humans
Idioma:
En
Revista:
FEBS Lett
Año:
2024
Tipo del documento:
Article