The association of triglyceride-glucose index with major adverse cardiovascular and cerebrovascular events after acute myocardial infarction: a meta-analysis of cohort studies.
Nutr Diabetes
; 14(1): 39, 2024 Jun 06.
Article
en En
| MEDLINE
| ID: mdl-38844442
ABSTRACT
BACKGROUND:
Insulin resistance (IR) is indicated to be linked with adverse outcomes of acute myocardial infarction (AMI), for its pro-inflammatory and pro-thromboplastic function. The triglyceride-glucose (TyG) index is a newly developed substitute marker for IR. The aim of this pooled analysis was to provide a summary of the relationship of TyG index with occurrences of major adverse cardiovascular and cerebrovascular events (MACCEs) among populations suffering from AMI.METHODS:
Cohorts reporting multivariate-adjusted hazard ratios of TyG index with MACCEs or its independent events were identified through systematically searching PubMed, MEDLINE, Web of science, Embase and Cochrane databases. Results were combined using a random-effects model.RESULTS:
21 cohorts comprising 20403 individuals were included. Compared to individuals in the lowest TyG category, patients in the highest TyG category exhibited elevated risks of both MACCEs (P < 0.00001) and all-cause death (P < 0.00001). These findings were in line with the results as TyG analyzed as continuous variables (MACCEs P = 0.006; all-cause death P < 0.00001). Subgroup analysis demonstrated that diabetic status, type of AMI, nor the reperfusion therapy did not destruct this correlation (for subgroups, all P < 0.05).CONCLUSION:
All these indicated that higher TyG index could potentially predict MACCEs and all-cause death in patients with AMI as an independent indicator.
Texto completo:
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Base de datos:
MEDLINE
Asunto principal:
Triglicéridos
/
Glucemia
/
Trastornos Cerebrovasculares
/
Infarto del Miocardio
Límite:
Humans
Idioma:
En
Revista:
Nutr Diabetes
Año:
2024
Tipo del documento:
Article
País de afiliación:
China