Your browser doesn't support javascript.
loading
Copper-catalyzed asymmetric allylic substitution of racemic/meso substrates.
Li, Jun; Huang, Junrong; Wang, Yan; Liu, Yuexin; Zhu, Yuxiang; You, Hengzhi; Chen, Fen-Er.
Afiliación
  • Li J; School of Science, Harbin Institute of Technology (Shenzhen) Taoyuan Street, Nanshan District Shenzhen 518055 China youhengzhi@hit.edu.cn.
  • Huang J; School of Science, Harbin Institute of Technology (Shenzhen) Taoyuan Street, Nanshan District Shenzhen 518055 China youhengzhi@hit.edu.cn.
  • Wang Y; Green Pharmaceutical Engineering Research Center, Harbin Institute of Technology (Shenzhen) Taoyuan Street, Nanshan District Shenzhen 518055 China.
  • Liu Y; School of Science, Harbin Institute of Technology (Shenzhen) Taoyuan Street, Nanshan District Shenzhen 518055 China youhengzhi@hit.edu.cn.
  • Zhu Y; School of Science, Harbin Institute of Technology (Shenzhen) Taoyuan Street, Nanshan District Shenzhen 518055 China youhengzhi@hit.edu.cn.
  • You H; School of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University Shenzhen 518107 China zhuyx86@mail.sysu.edu.cn.
  • Chen FE; School of Science, Harbin Institute of Technology (Shenzhen) Taoyuan Street, Nanshan District Shenzhen 518055 China youhengzhi@hit.edu.cn.
Chem Sci ; 15(22): 8280-8294, 2024 Jun 05.
Article en En | MEDLINE | ID: mdl-38846404
ABSTRACT
The synthesis of enantiomerically pure compounds is a pivotal subject in the field of chemistry, with enantioselective catalysis currently standing as the primary approach for delivering specific enantiomers. Among these strategies, Cu-catalyzed asymmetric allylic substitution (AAS) is significant and irreplaceable, especially when it comes to the use of non-stabilized nucleophiles (pK a > 25). Although Cu-catalyzed AAS of prochiral substrates has also been widely developed, methodologies involving racemic/meso substrates are highly desirable, as the substrates undergo dynamic processes to give single enantiomer products. Inspired by the pioneering work of the Alexakis, Feringa and Gennari groups, Cu-catalyzed AAS has been continuously employed in deracemization and desymmetrization processes for the synthesis of enantiomerically enriched products. In this review, we mainly focus on the developments of Cu-catalyzed AAS with racemic/meso substrates over the past two decades, providing an explicit outline of the ligands employed, the scope of nucleophiles, the underlying dynamic processes and their practical applications.

Texto completo: 1 Base de datos: MEDLINE Idioma: En Revista: Chem Sci Año: 2024 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Idioma: En Revista: Chem Sci Año: 2024 Tipo del documento: Article