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No causal association between insomnia and bladder cancer: a bidirectional two-sample Mendelian randomization study.
Du, Lihuan; Wang, Bohan; Wen, Jiaming; Zhang, Nan.
Afiliación
  • Du L; Department of Urology, The Second Affiliated Hospital of Zhejiang University, No. 88 Jiefang Road, Hangzhou, 310009, China. dlh1984@zju.edu.cn.
  • Wang B; Department of Urology, The Second Affiliated Hospital of Zhejiang University, No. 88 Jiefang Road, Hangzhou, 310009, China.
  • Wen J; Department of Urology, The Second Affiliated Hospital of Zhejiang University, No. 88 Jiefang Road, Hangzhou, 310009, China.
  • Zhang N; Department of Urology, The Second Affiliated Hospital of Zhejiang University, No. 88 Jiefang Road, Hangzhou, 310009, China.
Eur J Med Res ; 29(1): 316, 2024 Jun 08.
Article en En | MEDLINE | ID: mdl-38849949
ABSTRACT

BACKGROUND:

Previous observational studies have indicated a potential link between insomnia and bladder cancer, yet the underlying causal relationship remains uncertain. The current study employed a bidirectional two-sample Mendelian randomization (MR) analysis to investigate this association.

METHODS:

A two-sample MR analysis was conducted utilizing publicly available summary data from genome-wide association studies (GWAS) on insomnia and bladder cancer. Various regression methods including the inverse variance weighted (IVW), weighted median, MR-Egger, weighted mode, and simple mode methods were employed for the MR analysis. The presence of pleiotropy and heterogeneity in the MR results was also assessed. Furthermore, additional sensitivity tests were performed to mitigate potential biases.

RESULTS:

No significant causal relationship was detected between insomnia and bladder cancer using IVW method (OR = 0.761, 95% CI 0.996-1.005; P = 0.76). Similarly, the IVW model did not reveal any causal effect of bladder cancer on the risk of insomnia (OR = 1.47, 95% CI 0.772-2.799; P = 0.24). Consistent results were obtained from the other four methods employed. There was no evidence of horizontal pleiotropy or heterogeneity in our MR analysis (P > 0.05). The sensitivity analyses further supported the reliability of the estimated causal effects.

CONCLUSIONS:

This study presents no evidence for a causal relationship between insomnia and bladder cancer.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Neoplasias de la Vejiga Urinaria / Estudio de Asociación del Genoma Completo / Análisis de la Aleatorización Mendeliana / Trastornos del Inicio y del Mantenimiento del Sueño Límite: Humans Idioma: En Revista: Eur J Med Res Asunto de la revista: MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Neoplasias de la Vejiga Urinaria / Estudio de Asociación del Genoma Completo / Análisis de la Aleatorización Mendeliana / Trastornos del Inicio y del Mantenimiento del Sueño Límite: Humans Idioma: En Revista: Eur J Med Res Asunto de la revista: MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: China