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Autochtonal case of chronic, unifocal, pulmonary paracoccidioidomycosis with methotrexate use, in Salvador ‒ Brazil.
Franco, Priscila de Abreu; Araújo Neto, Cesar Augusto de; da Silva, Sonia Regina Leite; Coelho Filho, João Carlos; Brites, Carlos; Pereira-Silva, Jorge Luiz.
Afiliación
  • Franco PA; Hospital São Rafael, Instituto D'Or de Pesquisa e Ensino (IDOR), Salvador, BA, Brazil.
  • Araújo Neto CA; Universidade Federal da Bahia, Departamento de Medicina, Salvador, BA, Brazil.
  • da Silva SRL; Hospital São Rafael, Instituto D'Or de Pesquisa e Ensino (IDOR), Salvador, BA, Brazil.
  • Coelho Filho JC; Fundação José Silveira, Salvador, BA, Brazil.
  • Brites C; Universidade Federal da Bahia, Departamento de Medicina, Salvador, BA, Brazil. Electronic address: crbrites@gmail.com.
  • Pereira-Silva JL; Hospital São Rafael, Instituto D'Or de Pesquisa e Ensino (IDOR), Salvador, BA, Brazil.
Braz J Infect Dis ; 28(3): 103768, 2024.
Article en En | MEDLINE | ID: mdl-38851212
ABSTRACT
We report an autochthonous case of mild unifocal chronic pulmonary paracoccidioidomycosis in a 48-year-old previously healthy woman with no history of possible environmental exposures in endemic rural areas, supposedly resulting from reactivation of a latent pulmonary focus secondary to the use of methotrexate for the control of Chikungunya arthropathy. Laboratory investigation ruled out other immunosuppression. Her only symptoms were a dry cough and chest pain. Diagnosis confirmed by needle lung biopsy. There were no abnormalities on physical examination nor evidence of central nervous system involvement. MRI of the total abdomen showed no involvement of other organs. Computed chest tomography showed a favorable evolution under the use of itraconazole (200 mg/day). Different tomographic presentations findings are highlighted when performed before and after treatment.

CONCLUSIONS:

PCM should be considered even in a woman without a history of consistent environmental exposure and in a non-endemic geographic area.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Paracoccidioidomicosis / Metotrexato / Enfermedades Pulmonares Fúngicas Límite: Female / Humans / Middle aged País/Región como asunto: America do sul / Brasil Idioma: En Revista: Braz J Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2024 Tipo del documento: Article País de afiliación: Brasil

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Paracoccidioidomicosis / Metotrexato / Enfermedades Pulmonares Fúngicas Límite: Female / Humans / Middle aged País/Región como asunto: America do sul / Brasil Idioma: En Revista: Braz J Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2024 Tipo del documento: Article País de afiliación: Brasil