Factors Affecting Postpartum Bone Mineral Density in a Clinical Trial of Vitamin D Supplementation.
J Womens Health (Larchmt)
; 33(7): 887-900, 2024 Jul.
Article
en En
| MEDLINE
| ID: mdl-38853682
ABSTRACT
Background:
Few studies evaluate the effects of vitamin D status and supplementation on maternal bone mineral density (BMD) during lactation and further lack inclusion of diverse racial/ethnic groups, body mass index (BMI), or physical activity.Objective:
Determine the effects of vitamin D treatment/status, feeding type, BMI, race/ethnicity, and physical activity on postpartum women's BMD to 7 months.Methods:
Women with singleton pregnancies beginning 4-6 weeks' postpartum were randomized into two treatment groups (400 or 6400 IU vitamin D/day). Participant hip, spine, femoral neck, and whole-body BMD using Dual-energy X-ray absorptiometry (DXA Hologic), serum 25-hydroxyvitamin D [25(OH)D] (RIA; Diasorin), BMI, and physical activity were measured at 1, 4, and 7 months postpartum. A general linear mixed modeling approach was undertaken to assess the effects of vitamin D status [both serum 25(OH)D concentrations and treatment groups], feeding type, race/ethnicity, BMI, and physical activity on BMD in postpartum women.Results:
During the 6-month study period, lactating women had 1-3% BMD loss in all regions compared with 1-3% gain in nonlactating women. Higher maternal BMI was associated with less bone loss in femoral neck and hip regions. Black American women had less BMD loss than White/Caucasian or Hispanic lactating women in spine and hip regions. Exclusively breastfeeding women in the 6400 IU vitamin D group had less femoral neck BMD loss than the 400 IU group at 4 months sustained to 7 months. Physical activity was associated with higher hip BMD.Conclusion:
While there was BMD loss during lactation to 7 months, the loss rate was less than previously reported, with notable racial/ethnic variation. Breastfeeding was associated with loss in BMD compared with formula-feeding women who gained BMD. Higher BMI and physical activity independently appeared to protect hip BMD, whereas higher vitamin D supplementation appeared protective against femoral neck BMD loss.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Vitamina D
/
Lactancia
/
Absorciometría de Fotón
/
Índice de Masa Corporal
/
Densidad Ósea
/
Suplementos Dietéticos
/
Periodo Posparto
Límite:
Adult
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
J Womens Health (Larchmt)
/
J. womens health (Larchmt.)
/
Journal of women's health (Larchmont)
Asunto de la revista:
GINECOLOGIA
/
SAUDE DA MULHER
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos