Beyond the danger signal: RNA aggregates orchestrate immunotherapy.

Shubhra, Quazi T H; Feczkó, Tivadar; Cai, Qiang

Shubhra, Quazi T H; Feczkó, Tivadar; Cai, Qiang.

Afiliación

Shubhra QTH; Institute of Chemistry, University of Silesia in Katowice, Szkolna 9, 40-003 Katowice, Poland; Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan 430060, China. Electronic address: tanminul-haque-shubra.quazi@us.edu.pl.
Feczkó T; Institute of Materials and Environmental Chemistry, HUN-REN Research Centre for Natural Sciences, Magyar Tudósok Körútja 2, H-1117 Budapest, Hungary; Faculty of Engineering, University of Pannonia, Egyetem u. 10, H-8200, Veszprém, Hungary.
Cai Q; Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan 430060, China.

Trends Mol Med ; 30(8): 702-704, 2024 Aug.

Article en En | MEDLINE | ID: mdl-38866645

ABSTRACT

ABSTRACT

Mendez-Gomez et al. recently demonstrated the transformative potential of RNA-lipid particle aggregates (RNA-LPAs) in immunotherapy. By reprogramming the tumor microenvironment (TME) and potentiating antitumor immunity, RNA-LPAs target primary tumors and elicit robust systemic immunity. This innovative platform holds promise for translating preclinical success into tangible clinical benefits.

Asunto(s)

Inmunoterapia; Neoplasias; ARN; Microambiente Tumoral; Humanos; Inmunoterapia/métodos; Microambiente Tumoral/inmunología; Neoplasias/terapia; Neoplasias/inmunología; Animales; ARN/uso terapéutico; ARN/inmunología; ARN/química; Lípidos/química

Palabras clave

cancer vaccine; immunotherapy; lipid particle aggregates (LPAs); mRNA; tumor microenvironment (TME)

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: ARN / Microambiente Tumoral / Inmunoterapia / Neoplasias Límite: Animals / Humans Idioma: En Revista: Trends Mol Med Asunto de la revista: BIOLOGIA MOLECULAR Año: 2024 Tipo del documento: Article

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