Eye Adult Changes in Thought (Eye ACT) Study: Design and Report on the Inaugural Cohort.
J Alzheimers Dis
; 100(1): 309-320, 2024.
Article
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| MEDLINE
| ID: mdl-38875039
ABSTRACT
Background:
Conflicting research on retinal biomarkers of Alzheimer's disease and related dementias (AD/ADRD) is likely related to limited sample sizes, study design, and protocol differences.Objective:
The prospective Eye Adult Changes in Thought (Eye ACT) seeks to address these gaps.Methods:
Eye ACT participants are recruited from ACT, an ongoing cohort of dementia-free, older adults followed biennially until AD/ADRD, and undergo visual function and retinal imaging assessment either in clinic or at home.Results:
330 participants were recruited as of 03/2023. Compared to ACT participants not in Eye ACT (Nâ=â1868), Eye ACT participants (Nâ=â330) are younger (mean age 70.3 versus 71.2, pâ=â0.014), newer to ACT (median ACT visits since baseline 3 versus 4, pâ<â0.001), have more years of education (17.7 versus 16.2, pâ<â0.001) and had lower rates of visual impairment (12% versus 22%, pâ<â0.001). Compared to those seen in clinic (Nâ=â300), Eye ACT participants seen at home (Nâ=â30) are older (77.2 versus 74.9, pâ=â0.015), more frequently female (60% versus 49%, pâ=â0.026), and have significantly worse visual acuity (71.1 versus 78.9 Early Treatment Diabetic Retinopathy Study letters, pâ<â0.001) and contrast sensitivity (-1.9 versus -2.1 mean log units at 3 cycles per degree, pâ=â0.002). Cognitive scores and retinal imaging measurements are similar between the two groups.Conclusions:
Participants assessed at home had significantly worse visual function than those seen in clinic. By including these participants, Eye ACT provides a unique longitudinal cohort for evaluating potential retinal biomarkers of dementia.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Enfermedad de Alzheimer
Límite:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Alzheimers Dis
Asunto de la revista:
GERIATRIA
/
NEUROLOGIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos