Neuroaxonal damage in natalizumab-treated MS patients: The role of JCV antibody titres.
Mult Scler
; : 13524585241260977, 2024 Jun 14.
Article
en En
| MEDLINE
| ID: mdl-38877721
ABSTRACT
BACKGROUND:
While John Cunningham virus (JCV) is known to cause neuronal damage in progressive multifocal leukoencephalopathy (PML) among natalizumab-treated MS patients, its association with axonal loss in non-PML conditions remains unclear.METHODS:
In a cohort of 128 natalizumab-treated MS patients, serum neurofilament (sNfL) levels and JCV antibody titres were measured.RESULTS:
Among 128 patients (mean age = 38.4 years, 71.9% female), 51 (40%) were JCV positive. NfL levels increased by 15.3% for JCV index <0.7 (95% confidence interval [CI] = 0.963-1.381), by 18.6% for index 0.7-1.5 (95% CI = 1.009-1.394) and by 21.1% for index >1.5 (95% CI = 1.040-1.409) compared to JCV negative patients.CONCLUSION:
These findings indicate a potential link between JCV burden and neuroaxonal degeneration in natalizumab-treated MS patients.
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Base de datos:
MEDLINE
Idioma:
En
Revista:
Mult Scler
Asunto de la revista:
NEUROLOGIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Italia